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HENRY HE
Shanghai
PROFILE REPRESENTATIVE MATTERS AND CASES OTHER INFORMATION Further Reading
MR. HE SPECIALIZES IN CROSS-BORDER TRANSACTIONS INVOLVING COMPLEX BUSINESS, INTELLECTUAL PROPERTY, OPERATIONAL AND LEGAL ISSUES, INCLUDING STRATEGIC PARTNERSHIPS, PRODUCT AND TECHNOLOGY LICENSING (IN/OUT), ASSET ACQUISITIONS AND DIVESTITURES, PLATFORM DISCOVERY AND OPTION DEALS. ADDITIONALLY, MR. HE COUNSELS LIFE SCIENCES CLIENTS ON DAY-TO-DAY OPERATIONAL MATTERS INVOLVING CLINICAL TRIALS, REGULATORY COMPLIANCE, DRUG SUPPLY AND PROMOTION, RESEARCH AND COMMERCIALIZATION COLLABORATIONS.
Education
East China University of Political Sciences and Law, LL.B; LL.M
University of Wisconsin-Madison, LL.M
Professional Qualification
Admitted to practice in Massachusetts
Admitted to practice in PRC
Work Language
Mandarin
English
Professional Background
Mr. He joined Fangda as a partner in 2023. Prior to joining the firm, Mr. He worked as the Board Secretary, Associate Vice President and General Counsel at CStone Pharmaceuticals (2616.HK), a well-renowned public biopharmaceutical company. Before moving in-house, Mr. He had worked at two reputable international law firms (Cooley LLP and Baker & McKenzie) for many years, representing venture capital funds, emerging companies and multinational corporations with exposure to early-stage financing and pre-IPO restructuring, licensing, venture capital, offshore/onshore ESOP matters and corporate M&A.
PROFILE
REPRESENTATIVE MATTERS AND CASES
- Represented Health Hope Pharma (HHP) in its entering into a global licensing and collaboration agreement with Gilead Sciences for Encequidar, a first-in-class P-glycoprotein (P-gp) inhibitor in the field of virology.
- Represented Qyuns Therapeutics (2509.HK) in granting Caldera Therapeutics (NewCo) a global exclusive license to develop, manufacture, and commercialize QX030N (a bispecific antibody program in the field of autoimmune diseases) while acquiring an equity interests in NewCo. Caldera Therapeutics is co-founded by prominent investors Lilly Asia Ventures, Atlas Venture, and venBio.
- Represented Genrix Bio (688443.SH) in granting Cullinan Therapeutics (CGEM.Nasdaq) an exclusive license to develop, manufacture and commercialize Genrix Bio's Velinotamig, a clinical-stage BCMAxCD3 bispecific T cell engager for autoimmune diseases in the ex-Greater China territory.
- Represented Kanghua (300841.SZ) in granting HilleVax (HLVX.Nasdaq) the exclusive rights to develop, manufacture and commercialize Kanghua’s hexavalent virus-like particle (VLP) vaccine candidate for norovirus in the ex-Greater China territory.
- Represented TJ Bio to enter into a strategic collaboration with Sanofi for developing, manufacturing and commercializing the globally innovative asset CD73 monoclonal antibody (Uliledlimab) in Greater China.
- Represented Lepu Biopharma (2157.HK) in its grant of a global exclusive license to Excalipoint Therapeutics (NewCo) for the development, manufacture, and commercialization of two T-cell engager pipelines and the acquisition of a minority equity stake in NewCo. The Series A financing of NewCo was jointly led by prominent investors HongShan Capital, YuanBio Capital, and Apricot Capital.
- Represented Hansoh Pharma (3692.HK) in its transaction where Hansoh Pharma exclusively granted the ex-China development, manufacture, and commercialization rights of three central nervous system (CNS) drug therapies to a newly established corporate entity (NewCo) backed by U.S. venture capital funds, while obtaining a minority equity stake in such NewCo.
- Represented LaNova Medicines in granting MSD an exclusive global to develop, manufacture and commercialize LM-299, a novel investigational PD-1/VEGF bispecific antibody, including handling upstream licensing arrangements, under which LaNova will receive an upfront payment of US$588 million and is eligible to receive up to US$2.7 billion in milestone payments associated with the progress of LM-299 across multiple indications.
- Represented Jikang Therapeutics in granting BioAge Labs (BIOA.Nasdaq) an exclusive option to through joint research collaboration in-license Jikang's novel apelin receptor (APJ) agonist nanobody program and if exercised, to globally develop, manufacture and commercialize Jikang's novel APJ agonist nanobody.
- Represented Zelgen in its out-licensing collaboration with Merck to grant an exclusive commercialization rights for Zelgen’s self-developed rhTSH injection in Chinese mainland.
- Represented Hengrui Pharmaceuticals (600276.SH) in its out-licensing partnership with Aiolos Bio with respect to the exploitation of Hengrui's innovative anti-TSLP monoclonal antibody (SHR-1905) in ex-Greater China territory.
- Represented CStone Pharmaceuticals on entering into the Asset Purchase Agreement and the Transition Plan Agreement with Les Laboratoires Servier pursuant to which CStone sold and Servier acquired the TIBSOVO® (Ivosidenib, IDH1 inhibitor) business and any goodwill thereof, including the transferred assets, in Greater China and Singapore.
- Represented Bao Pharmaceutical and its wholly-owned subsidiary Centergene Pharmaceuticals to enter into a Licensing Agreement with Organon for exploiting the innovative investigational asset in assisted reproductive technology (ART), SJ02, a long-acting FSH in BLA Process in China Mainland.
- Represented CSPC's wholly-owned subsidiary Shanghai JMT-BIO to enter into an exclusive license agreement with Jiangsu Alphamab for developing and commercializing JSKN003 (a biparatopic HER2-targeting antibody-drug conjugate/ADC) in Mainland China, with upfront payment plus near-term development milestones amounting to approx. US$100 million.
- Represented CStone Pharmaceuticals in strategic out-licensing partnership for commercialization of Sugemalimab (anti-PD-L1 mAb) with Ewopharma in Switzerland and Central & Eastern European countries, with SteinCares in in Latin America, and with Pharmalink in the Middle East and North Africa countries.
- Represented Sanegene Bio on its strategic collaboration with Huadong Medicine (0963.SZ) with respect to the siRNA drug development for chronic metabolic diseases.
- Represented CStone Pharmaceuticals in out-licensing of exclusive commercialization right related to anti-PD-1 monoclonal antibody (nofazinlimab) in mainland China to 3SBio Inc.
- Represented TargetRx in an exclusive commercialization transaction with Simcere Zaiming with respect to its clinical-stage anti-tumor candidate drug, ALK/ROS1 dual receptor tyrosine kinase inhibitor (TGRX-326) in mainland China, with an upfront payment exceeding US$20 million.
- Represented MingMed Biotech in its out-licensing partnership with Elanco Animal Health with respect to its JAK small molecule inhibitor for companion animals in Greater China .
- Represented UCB on its strategic collaboration with BioRay with respect to the exclusive commercialization of IL-17A and IL-17F inhibitor Bimzelx® (bimekizumab) in China.
- Represented Anheart Therapeutics in granting an exclusive commercialization right with respect to Anheart’s lead drug candidate Taletrectinib to Innovent for PRC market and to Nippon Kayaku, a Japanese listed company, for Japan market, respectively.
- Represented AstraZeneca in a co-promotion collaboration with Daiichi Sankyo for the antibody conjugated product DS8201 in the Chinese market according to a global licensing agreement for such product.
- Represented CStone Pharmaceuticals in granting an exclusive commercial promotion right to Allist (688578.SH), with respect to its approved RET inhibitor Gavreto® (Pralsetinib) in mainland China.
- Advised on the exclusive collaboration and license agreement with LegoChem Biosciences Inc. to develop, manufacture and commercialize LCB71 (ROR1 ADC) for entire world excluding Korea.
- Represented CStone Pharmaceuticals on the out-licensing of CTLA-4 mAb (CS1002)’s development and commercialization rights in Greater China to Hengrui Pharmaceuticals (600276.SH).
- Represented CStone Pharmaceuticals on China MAH transfer for GAVRETO® (Pralsetinib) partnering with Roche and Blueprint on drug supply, manufacturing technology transfer, global clinical development and regulatory matters.
- Representing various multinational and domestic life sciences clients including AstraZeneca, Biogen, Boehringer Ingelheim, Brii Biosciences, CStone Pharmaceuticals, Everest Medicines, Hasten Pharmaceuticals, Hengrui Pharmaceuticals, IASO, Insilico Medicine, Laekna Therapeutics, LaNova Medicines, Legend Biotech, MSD, Novartis AG, Roche Pharmaceuticals, Sanegene Bio, InnoRNA, UCB, Vera Therapeutics, WuXi AppTec, Yiling Pharma and Zai Lab, on regulatory advisory and compliance matters arising from day-to-day operations, e.g., research and development projects, clinical trials, HGR (human genetic resources) matters, marketing authorization, drug product supply, distribution, advertising and promotion.
- Represented AnHeart Therapeutics in Nuvation Bio (NUVB, NYSE)’s acquisition of AnHeart Therapeutics in an all-stock transaction.
- Represented Kyowa Kirin in its business restructuring of the APAC region through a serial transactions of transferring all rights and interests of Kyowa Kirin China to Hong Kong WinHealth Pharma Group ("WinHealth") and granting a license to WinHealth to commercialize and manufacture five original branded commercial-stage drugs in China and to commercialize two global products in China.
- Represented CStone Pharmaceuticals on Series B financing, pre-IPO restructuring, licensing, early-stage collaboration and offshore/onshore ESOP-related matters.
- Represented Synvida Bio in its series A financing, with an aggregate fundraising amount of approx. RMB200 million, led by Longpan Investment and Shanghai Healthcare Capital (SHC).
- Represented Eight Roads Ventures as the lead investor in its equity investment in the Series A financing of New Trials Medical Technology with the aggregate fundraising size over RMB100million.
- Represented Qiming Ventures and BioTrack Capital as the lead investors in its equity investment in the Series C financing of Bioheng Therapeutics (a clinical-stage biotech focusing on CAR-T therapies).
- Represented Shanghai Healthcare Capital in its investment as lead investor in Series B+ financing of Hexaell Biotech (a clinical-stage biotech focusing on developing novel cell therapies and regenerative medicines for severe liver diseases) with an aggregate fundraising exceeding RMB200 million.
- Represented a China biotech company in its joint venture collaboration with a leading Hong Kong listed pharmaceutical company with respect to distribution and commercialization of certain novel pharmaceutical drugs in China.
- Represented BioBay in its forming a joint venture, Suqiao Pharma (an one-stop CDMO service provider) with C-Bridge Capital in Suzhou.
- Represented various venture capital funds including Eight Roads Ventures, BioTrack Capital, Shanghai Healthcare Capital, Qiming Ventures, OrbiMed, GGV, Matrix China Partners, Decheng Capital in investments/exit transactions across life science, healthcare, e-commerce, financial services, telecommunication and education sectors.
- Represented various emerging growth companies including AlphaMab Oncology, Curative Medical, Genebox, ABM Therapeutic, Quantifeed, Cashshield, Carousell, Gshopper, Yamibuy, Hycor on equity financings (covering series seed through pre-IPO round), restructuring and asset acquisitions.
OTHER INFORMATION
- Co-author, "Encountering and Anchoring Opportunities in an Era of Uncertainty: Exploring the Trends and Core Risks of Mergers and Acquisitions of Chinese Biotech Companies", Legal 500 (September 2024)(1)
- Co-author, "China life sciences: Transaction insights and notable industry trends", Legal 500 (February 2024)(2)
- Co-author, "Life Sciences Yearbook 2024: China life sciences Q&A ", Legal 500 (February 2024)(3)
